GLUCOSE DEPRIVATION-INDUCED DISULFIDPTOSIS IN HUMAN NUCLEUS PULPOSUS CELLS: A NOVEL PATHOLOGICAL MECHANISM OF INTERVERTEBRAL DISC DEGENERATION

Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration

Abstract Background Limited supply of certain nutrients and deregulation of nucleus pulposus (NP) plays a key role in the pathogenesis of intervertebral disc degeneration (IVDD).However, whether nutrient deprivation-induced cell death, particularly disulfidptosis, contributes to the depletion of NP cells and the development of IVDD, is unknown.Meth

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